Insiders know a lot about the companies they work for, so watching their actions can help bank some serious profits. These transactions can be monitored by the public through forms 3, 4, and 5 filed with the U.S. Securities and Exchange Commission (SEC). Here are the top 5 insider buys from last week, which can be useful when creating a watchlist of stocks with a potential catalyst for this week:

1. Lamar Advertising Company (LAMR) - 10% owner Edward McDermott purchase a substantial block of shares valued at over $20 million.
2. Stericycle Inc. (SRCL) - The company's chairman and director each purchased substantial blocks of shares valued at over $10 million.
3. Orbitz Worldwide, Inc. (OWW) - Par Capital Management Inc. purchased over $12 million in new shares.
4. Saks Inc. (SKS) - Inmobiliaria Carso purchased over a million shares for nearly $10 million.
5. Hearst Argyle Television Inc. (HTV) - Hearst Family Trust purchased nearly a half million shares in a transaction worth some nearly $10 million.

Cardiome Pharma Corp. (NDAQ: CRME) shares moved sharply higher today after the company announced positive phase IIb results for its oral Vernakalant drug. The experimental drug reduced the rate of abnormal heart rhythms in patients with recurrent atrial fibrilation - a condition in which the heart's top two chambers quiver instead of beating regularly, thereby reducing the heart's ability to pump blood efficiently.

Cardiome said it would move forwards with phase III study and seek a development partner or strategic buyer for the entire company. Investors clearly applauded the move since the likelihood of a strategic buyer is substantially higher with every development milestone that they pass. These latest results demonstrated that the dosing group significantly reduced the rate of arrial fibrillation relapse as compared to the placebo group.

"We are delighted to report clearly positive clinical results from our vernakalant (oral) program, which continue to support our belief in the exciting potential of vernakalant as a therapy for atrial fibrillation," said Bob Rieder, Chairman and Chief Executive Officer of Cardiome. "With 949 patients and subjects exposed to vernakalant (oral) in this development program, we now have an extensive safety and efficacy dataset to guide us as we move this exciting clinical program forward and finalize our strategic discussions with interested parties."

Shares of Cardiome Pharma rose 27.46% to $10.63 on the news today.

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Freddie Mac (NYSE: FRE) and Fannie Mae (NYSE: FNM) shares are finding themselves under increased pressure as concerns about liquidity continue to mount. Many regulators are now calling for government intervention in order to save the government-subsidized entities and preserve the struggling housing market from a larger collapse. Unfortunately for shareholders, federal bailouts are only aimed at saving the company and not necessarily its shareholders.

A government takeover of both organizations is among several options being weighed by the Bush Administration. Officials may push for the firms, which own or guarantee almost half of the $12 trillion in home loans in the United States. Such a government takeover is likely to make the common stock of each company worthless, since paying off shareholders with taxpayer dollars may present a problem to perhaps everyone in the USA (minus those shareholders).

Fannie Mae has lost about 80 percent of its value during the past year while Freddie Mac has tumbled more than 85 percent during the same time. The reason is simply because many of these loans are going bad and requiring the companies to come up with capital that they are unable to raise. The government is expected to wait until these losses hit some $77 billion before it would be compelled to start a rescue.

Others insist that a government bailout would be unlikely because the two institutions have some $1.5 trillion in un-pledged assets and access to the debt market. Some insist that Fannie Mae would have to lose $40 billion immediately and Freddie Mac would have to lose $37 billion immediately in order to be considered insolvent. Housing prices would have to decline 40% nationally and delinquencies would have to rise as much as 10 fold to 12 percent to reach critical levels, according to these analysts.

In the end, there is still a lot of uncertainty as to whether or not the two housing market giants are in trouble. If they are, however, it is clear that shareholders will likely lose out in the event of a bailout. The only people that can hope to get their money back would be bond holders.

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